Structure of PDB 1bel Chain A Binding Site BS02

Receptor Information

>1bel Chain A (length=124) Species: 9913 (Bos taurus)

KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHES
LADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTT
QANKHIIVACEGNPYVPVHFDASV

Ligand information

• Ligand ID: MOH
• InChI: InChI=1S/CH4O/c1-2/h2H,1H3
• InChIKey: OKKJLVBELUTLKV-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.352
  OpenEye OEToolkits 1.7.0: CO
  ACDLabs 11.02: OC
• Formula: C H4 O
• Name: METHANOL
• ChEMBL: CHEMBL14688
• PDB chain: 1bel Chain A Residue 170

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1bel Structure of crystal form IX of bovine pancreatic ribonuclease A.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): Q60 S77
• Binding residue (residue number reindexed from 1): Q60 S77
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H12 K41 H119 F120 D121
• Catalytic site (residue number reindexed from 1): H12 K41 H119 F120 D121
• Enzyme Commision number: 4.6.1.18: pancreatic ribonuclease.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004519 endonuclease activity
• GO:0004522 ribonuclease A activity
• GO:0004540 RNA nuclease activity
• GO:0005515 protein binding
• GO:0016829 lyase activity

Biological Process

• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1bel, PDBe:1bel, PDBj:1bel
• PDBsum: 1bel
• PubMed: 15299907
• UniProt: P61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)