Structure of PDB 1ayp Chain A Binding Site BS02
Receptor Information
>1ayp Chain A (length=124) Species:
9606
(Homo sapiens) [
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NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCC
YKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
1ayp Chain A Residue 302 [
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Receptor-Ligand Complex Structure
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PDB
1ayp
A probe molecule composed of seventeen percent of total diffracting matter gives correct solutions in molecular replacement.
Resolution
2.57 Å
Binding residue
(original residue number in PDB)
F23 G25 Y112 N114
Binding residue
(residue number reindexed from 1)
F23 G25 Y112 N114
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
H27 G29 G31 H47 D48 Y51 Y66 D91
Catalytic site (residue number reindexed from 1)
H27 G29 G31 H47 D48 Y51 Y66 D91
Enzyme Commision number
3.1.1.4
: phospholipase A2.
Gene Ontology
Molecular Function
GO:0004623
phospholipase A2 activity
GO:0005509
calcium ion binding
GO:0005543
phospholipid binding
GO:0016787
hydrolase activity
GO:0046872
metal ion binding
GO:0047498
calcium-dependent phospholipase A2 activity
Biological Process
GO:0006629
lipid metabolic process
GO:0006644
phospholipid metabolic process
GO:0006954
inflammatory response
GO:0010744
positive regulation of macrophage derived foam cell differentiation
GO:0016042
lipid catabolic process
GO:0031640
killing of cells of another organism
GO:0034374
low-density lipoprotein particle remodeling
GO:0036335
intestinal stem cell homeostasis
GO:0042130
negative regulation of T cell proliferation
GO:0042742
defense response to bacterium
GO:0046337
phosphatidylethanolamine metabolic process
GO:0046470
phosphatidylcholine metabolic process
GO:0046473
phosphatidic acid metabolic process
GO:0050482
arachidonate secretion
GO:0050729
positive regulation of inflammatory response
GO:0050830
defense response to Gram-positive bacterium
GO:0070374
positive regulation of ERK1 and ERK2 cascade
GO:1902563
regulation of neutrophil activation
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0005739
mitochondrion
GO:0005741
mitochondrial outer membrane
GO:0005783
endoplasmic reticulum
GO:0005789
endoplasmic reticulum membrane
GO:0005886
plasma membrane
GO:0030141
secretory granule
GO:0048471
perinuclear region of cytoplasm
GO:0070062
extracellular exosome
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1ayp
,
PDBe:1ayp
,
PDBj:1ayp
PDBsum
1ayp
PubMed
15299314
UniProt
P14555
|PA2GA_HUMAN Phospholipase A2, membrane associated (Gene Name=PLA2G2A)
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