Structure of PDB 1aeu Chain A Binding Site BS02
Receptor Information
>1aeu Chain A (length=291) Species:
4932
(Saccharomyces cerevisiae) [
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LVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHI
SGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWIS
SGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDAGY
VRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPGGAANNVFTNEFY
LNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYAN
DQDKFFKDFSKAFEKLLEDGITFPKDAPSPFIFKTLEEQGL
Ligand information
Ligand ID
2MZ
InChI
InChI=1S/C4H6N2/c1-4-5-2-3-6-4/h2-3H,1H3,(H,5,6)
InChIKey
LXBGSDVWAMZHDD-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
n1ccnc1C
CACTVS 3.341
OpenEye OEToolkits 1.5.0
Cc1[nH]ccn1
Formula
C4 H6 N2
Name
2-METHYLIMIDAZOLE
ChEMBL
CHEMBL293391
DrugBank
ZINC
ZINC000008283844
PDB chain
1aeu Chain A Residue 296 [
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Receptor-Ligand Complex Structure
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PDB
1aeu
A ligand-gated, hinged loop rearrangement opens a channel to a buried artificial protein cavity.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
H175 T180 L232 D235
Binding residue
(residue number reindexed from 1)
H172 T177 L229 D232
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
R48 H52 H175 G191 D235
Catalytic site (residue number reindexed from 1)
R45 H49 H172 G188 D232
Enzyme Commision number
1.11.1.5
: cytochrome-c peroxidase.
Gene Ontology
Molecular Function
GO:0004601
peroxidase activity
GO:0020037
heme binding
Biological Process
GO:0006979
response to oxidative stress
GO:0034599
cellular response to oxidative stress
View graph for
Molecular Function
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Biological Process
External links
PDB
RCSB:1aeu
,
PDBe:1aeu
,
PDBj:1aeu
PDBsum
1aeu
PubMed
8673607
UniProt
P00431
|CCPR_YEAST Cytochrome c peroxidase, mitochondrial (Gene Name=CCP1)
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