Structure of PDB 1a36 Chain A Binding Site BS02

Receptor Information
>1a36 Chain A (length=544) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML
DHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTE
ARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGR
GNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV
SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYRED
WKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL
HPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL
FDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPA
KILSYNRANRAVAILCNHQEKSMMNLQTKIDAKKEQLADARRDLKSAKAD
AKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKL
NFLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1a36 A model for the mechanism of human topoisomerase I.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E356 G363 R364 H367 K374 K425 R488 A489 G490 N491 K493 T501 K532 D533 Q578 T585 A586 K587 R708 N745 K746 T747
Binding residue
(residue number reindexed from 1)		E142 G149 R150 H153 K160 K211 R274 A275 G276 N277 K279 T287 K318 D319 Q364 T371 A372 K373 R487 N524 K525 T526
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1a36, PDBe:1a36, PDBj:1a36
PDBsum1a36
PubMed9488652
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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