Structure of PDB 1a35 Chain A Binding Site BS02

Receptor Information
>1a35 Chain A (length=474) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKML
DHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTE
ARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGR
GNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV
SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYRED
WKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINL
HPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDL
FDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPA
KILSYNRANRAVAILCNHQRAQIALGTSKLNFLDPRITVAWCKKWGVPIE
KIYNKTQREKFAWAIDMADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1a35 Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K354 E356 F361 R362 G363 R364 H367 R488 A489 G490 N491 K493 T501 K532 N574 T585 A586 K587 T747
Binding residue
(residue number reindexed from 1)		K140 E142 F147 R148 G149 R150 H153 R274 A275 G276 N277 K279 T287 K318 N360 T371 A372 K373 T456
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1a35, PDBe:1a35, PDBj:1a35
PDBsum1a35
PubMed9488644
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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