Structure of PDB 1a2x Chain A Binding Site BS02

Receptor Information
>1a2x Chain A (length=158) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPT
KEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRI
FDRNADGYIDAEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEF
LKMMEGVQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1a2x Chain A Residue 161 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1a2x Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D139 N141 D143 R145 E150
Binding residue
(residue number reindexed from 1)		D138 N140 D142 R144 E149
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) V42
Catalytic site (residue number reindexed from 1) V41
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0031014 troponin T binding
GO:0046872 metal ion binding
Cellular Component
GO:0016460 myosin II complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:1a2x, PDBe:1a2x, PDBj:1a2x
PDBsum1a2x
PubMed9560191
UniProtP02586|TNNC2_RABIT Troponin C, skeletal muscle (Gene Name=TNNC2)

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