Structure of PDB 1a25 Chain A Binding Site BS02

Receptor Information
>1a25 Chain A (length=132) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS
ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFM
GSLSFGISELQKAGVDGWFKLLSQEEGEYFNV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1a25 Chain A Residue 291 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1a25 Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
Resolution2.7 Å
Binding residue
(original residue number in PDB)
M186 D187 D246 D248 D254
Binding residue
(residue number reindexed from 1)
M30 D31 D90 D92 D98
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
External links
PDB RCSB:1a25, PDBe:1a25, PDBj:1a25
PDBsum1a25
PubMed9817842
UniProtP68403|KPCB_RAT Protein kinase C beta type (Gene Name=Prkcb)

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