Structure of PDB 1a1r Chain A Binding Site BS02
Receptor Information
>1a1r Chain A (length=152) [
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VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
MR
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
1a1r Chain A Residue 901 [
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Receptor-Ligand Complex Structure
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PDB
1a1r
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
C123 C125 C171
Binding residue
(residue number reindexed from 1)
C69 C71 C117
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
H83 D107 G163 S165
Catalytic site (residue number reindexed from 1)
H29 D53 G109 S111
Enzyme Commision number
2.7.7.48
: RNA-directed RNA polymerase.
3.4.21.98
: hepacivirin.
3.4.22.-
3.6.1.15
: nucleoside-triphosphate phosphatase.
3.6.4.13
: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236
serine-type peptidase activity
Biological Process
GO:0006508
proteolysis
GO:0019087
transformation of host cell by virus
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Molecular Function
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Biological Process
External links
PDB
RCSB:1a1r
,
PDBe:1a1r
,
PDBj:1a1r
PDBsum
1a1r
PubMed
8861917
UniProt
P27958
|POLG_HCV77 Genome polyprotein
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