Structure of PDB 110m Chain A Binding Site BS02

Receptor Information

>110m Chain A (length=154) Species: 9755 (Physeter catodon)

MVLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHL
KTEAEMKASEDLKKHGVTVLTALGAILKKKGHHEAELKPLAQSHATKHKI
PIKYLEFISEAIIHVLHSRHPGNFGADAQGAMNKALELFRKDIAAKYKEL
GYQG

Ligand information

• Ligand ID: MNC
• InChI: InChI=1S/C2H3N/c1-3-2/h1H3
• InChIKey: ZRKSVHFXTRFQFL-UHFFFAOYSA-N
• SMILES:
  : isocyanide
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: C[N+]#[C-]
• Formula: C2 H3 N
• Name: METHYL ISOCYANIDE
• DrugBank: DB04337
• PDB chain: 110m Chain A Residue 156

Receptor-Ligand Complex Structure

Structure summary

• PDB: 110m Correlations between Bound N-Alkyl Isocyanide Orientations and Pathways for Ligand Binding in Recombinant Myoglobins
• Resolution: 1.77 Å
• Binding residue (original residue number in PDB): F43 H64 V68
• Binding residue (residue number reindexed from 1): F44 H65 V69
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.11.1.-
  1.7.-.-

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0005344 oxygen carrier activity
• GO:0016491 oxidoreductase activity
• GO:0019825 oxygen binding
• GO:0020037 heme binding
• GO:0046872 metal ion binding
• GO:0098809 nitrite reductase activity

Biological Process

• GO:0015671 oxygen transport
• GO:0019430 removal of superoxide radicals

Cellular Component

• GO:0005737 cytoplasm
• GO:0016528 sarcoplasm
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:110m, PDBe:110m, PDBj:110m
• PDBsum: 110m
• UniProt: P02185|MYG_PHYMC Myoglobin (Gene Name=MB)