Structure of PDB 7zeb Chain 9 Binding Site BS02

Receptor Information

>7zeb Chain 9 (length=171) Species: 9940 (Ovis aries) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TYKYVNLRMKSVTDRAAQTLLWTELIRGLGMTLSYLFREPATINYPFEKG
PLSPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEPRADGSRR
TTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLL
NNGDKWEAEIAANIQADYLYR

Ligand information

InChI=1S/4Fe.4S

LJBDFODJNLIPKO-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 2.0.7	[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385	S1[Fe]S[Fe]1.S2[Fe]S[Fe]2

Formula

Fe4 S4

Name

IRON/SULFUR CLUSTER

ChEMBL

DrugBank

ZINC

PDB chain

7zeb Chain 9 Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7zeb A universal coupling mechanism of respiratory complex I.
Resolution	3.8 Å
Binding residue (original residue number in PDB)	C77 I78 C80 K81 L82 C83 Y109 C126 P127 A130 I131
Binding residue (residue number reindexed from 1)	C72 I73 C75 K76 L77 C78 Y104 C121 P122 A125 I126
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003954	NADH dehydrogenase activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0032981	mitochondrial respiratory chain complex I assembly

	Cellular Component
GO:0005739	mitochondrion
GO:0016020	membrane

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External links

PDB	RCSB:7zeb, PDBe:7zeb, PDBj:7zeb
PDBsum	7zeb
PubMed	36104567
UniProt	A0A6P3TFB2

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