Structure of PDB 8qrn Chain 7 Binding Site BS02

Receptor Information
>8qrn Chain 7 (length=571) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKVRKNKDAVRRPQADPALLTPRSPVVTIMGHVDHGKTTLLDKFRKTQVA
AVETGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGAQVTDIVV
LVVAADDGVMKQTVESIQHAKDAQVPIILAVNKCDKAEADPEKVKKELLA
YDVVCEDYGGDVQAVPVSALTGDNLMALAEATVALAEMLELKADPNGPVE
GTVIESFTDKGRGLVTTAIIQRGTLRKGSVLVAGKCWAKVRLMFDENGKT
IDEAYPSMPVGITGWRDLPSAGEEILEVESEPRAREVVDWRKYEQEQEKG
QEDLKIIEEKRKEHKEAHQKAREKYGHLLWKKRSILRFLERKEQIPLKPK
EKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECELELVHFGVGDV
SANDVNLAETFDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIYRLVEDL
QEELSSRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCRVQKGQLEKQ
KKFKLTRNGHVIWKGSLTSLKHHKDDISIVKTGMDCGLSLDEDNMEFQVG
DRIVCYEEKQIQAKTSWDPGF
Ligand information
>8qrn Chain 5 (length=71) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguuggu
uauacccuucccguacuacca
<<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>.......<<.
.....>>...>>.>>>>....
Receptor-Ligand Complex Structure
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PDB8qrn GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Resolution2.98 Å
Binding residue
(original residue number in PDB)		V634 T635 K638 V643 S675 K677 K680 G693 S695
Binding residue
(residue number reindexed from 1)		V478 T479 K482 V487 S519 K521 K524 G537 S539
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005525 GTP binding
GO:0008135 translation factor activity, RNA binding
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0032790 ribosome disassembly
GO:0070124 mitochondrial translational initiation
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qrn, PDBe:8qrn, PDBj:8qrn
PDBsum8qrn
PubMed38969660
UniProtP46199|IF2M_HUMAN Translation initiation factor IF-2, mitochondrial (Gene Name=MTIF2)

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