Structure of PDB 8cst Chain 7 Binding Site BS02

Receptor Information
>8cst Chain 7 (length=400) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AALVPGVTQVDNKSGFLQKRPHRQHPGILKLPHVRLPQALANGAQLLLLG
SAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFGAVLHALRKT
TYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMD
FGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGEPY
IPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTGHF
LVLVENGTKAGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPCPQ
LTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRITQP
VLKRPRHVHCHLCCPDGHMQHAVLTARRHGRDLYRCARVSSWGDLLPVLT
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8cst Chain 7 Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8cst Principles of mitoribosomal small subunit assembly in eukaryotes.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		P332 C333 H335 C339 C347 C404
Binding residue
(residue number reindexed from 1)		P291 C292 H294 C298 C306 C363
Annotation score4
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:0180026 mitochondrial small ribosomal subunit assembly
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cst, PDBe:8cst, PDBj:8cst
PDBsum8cst
PubMed36482135
UniProtQ9H7H0|MET17_HUMAN Ribosome assembly protein METTL17, mitochondrial (Gene Name=METTL17)

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