Structure of PDB 8csr Chain 7 Binding Site BS02

Receptor Information
>8csr Chain 7 (length=402) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AALVPGVTQVDNKSGFLQKRPHRQHPGILKLPHVRLPQALANGAQLLLLG
SAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFLRGAVLHALR
KTTYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTL
MDFGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGE
PYIPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTG
HFLVLVENGTKAGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPC
PQLTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRIT
QPVLKRPRHVHCHLCCPDGHMQHAVLTARRHGRDLYRCARVSSWGDLLPV
LT
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8csr Chain 7 Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8csr Principles of mitoribosomal small subunit assembly in eukaryotes.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		M307 P332 C333 H335 C339 P340 Q341 C347 C404
Binding residue
(residue number reindexed from 1)		M268 P293 C294 H296 C300 P301 Q302 C308 C365
Annotation score4
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:0180026 mitochondrial small ribosomal subunit assembly
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8csr, PDBe:8csr, PDBj:8csr
PDBsum8csr
PubMed36482135
UniProtQ9H7H0|MET17_HUMAN Ribosome assembly protein METTL17, mitochondrial (Gene Name=METTL17)

[Back to BioLiP]