Structure of PDB 8ceo Chain 6 Binding Site BS02

Receptor Information
>8ceo Chain 6 (length=383) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGYAWEDEIKRSWDLVKVMASLVASIVEARKKRTAKKNITPYQRGIIRSL
ILTLDCSEAMLEKDLRPNRHAMIIQYAIDFVHEFFDQNPISQMGIIIMRN
GLAQLVSQVSGNPQDHIDALKSIRKQEPKGNPSLQNALEMARGLLLPVPA
HCTREVLIVFGSLSTTDPGDIHQTIDSLVSEKIRVKVLGLSAQVAICKEL
CKATNYGDESFYKILLDETHLKELFNEAVTPLPVNKINKGFTLVKMGFPT
RIFEDTPTFCSCHSKLVYGGYFCPNCHSKVCSLPTVCPCCDLMLILSTHL
ARSYHHLMPLKTFAEVPTTEKFRSEDCFSCQSRFPILKNHKNGKLLTSSR
YRCEDCKQEFCVDCDVFIHEILHNCPGCESKPV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ceo Chain 6 Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ceo Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C403 C406 C440
Binding residue
(residue number reindexed from 1)		C327 C330 C364
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006351 DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ceo, PDBe:8ceo, PDBj:8ceo
PDBsum8ceo
PubMed37014863
UniProtQ04673|SSL1_YEAST General transcription and DNA repair factor IIH subunit SSL1 (Gene Name=SSL1)

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