Structure of PDB 7pfo Chain 6 Binding Site BS02

Receptor Information
>7pfo Chain 6 (length=632) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEE
LIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRK
EIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELV
SGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVD
FQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVP
DVSKLSTPGARAETETEGIRGLRALGVRDLSYRLVFLACCVAPTNPTAES
IKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFG
GVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKAS
SAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIH
EAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSA
PIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEVYSLDDIRRYLLFA
RQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSE
AMARMHCCDEVQPKHVKEAFRLLNKSIIRVET
Ligand information
Receptor-Ligand Complex Structure
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PDB7pfo Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R189 G288 V289 R290
Binding residue
(residue number reindexed from 1)		R187 G276 V277 R278
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:1990518 single-stranded 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902969 mitotic DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pfo, PDBe:7pfo, PDBj:7pfo
PDBsum7pfo
PubMed34694004
UniProtQ14566|MCM6_HUMAN DNA replication licensing factor MCM6 (Gene Name=MCM6)

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