Structure of PDB 6qw6 Chain 5J Binding Site BS02

Receptor Information
>6qw6 Chain 5J (length=803) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPGLGRGATGFDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDK
RMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSI
PEVGDGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSM
IPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARN
LIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAA
ELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECC
PTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNT
QMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVI
GIGEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAY
FEKNHRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALA
FQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKL
EWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQ
GLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESV
RLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDAL
KKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKF
ELQHGTEEQQEEVRKRCESAEPRHGELWCAVSKDIANWQKKIGDILRLVA
GRI
Ligand information
>6qw6 Chain 5 (length=104) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acucugguuucucuucagaucgcauaaaucuuucgcacuaaagauuuccg
uggagaggaacaacucugaguccaauuuuuugaggccuugcuuuggcaag
gcua
<<<<.<<<<<<<<<<<<........<<<<<<<<......>>>>>>>>...
>>>>>>>>>>>....>.>>>>............<<<<<<<<....>>>>>
>>>.
Receptor-Ligand Complex Structure
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PDB6qw6 Mechanism of 5' splice site transfer for human spliceosome activation.
Resolution2.92 Å
Binding residue
(original residue number in PDB)		R111 R115 R116 E118 R119 R120 R123
Binding residue
(residue number reindexed from 1)		R51 R55 R56 E58 R59 R60 R63
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0008380 RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qw6, PDBe:6qw6, PDBj:6qw6
PDBsum6qw6
PubMed30975767
UniProtO94906|PRP6_HUMAN Pre-mRNA-processing factor 6 (Gene Name=PRPF6)

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