Structure of PDB 7d4i Chain 5H Binding Site BS02

Receptor Information
>7d4i Chain 5H (length=95) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDRFKGDDDIPYKERLFERQQGKRAINYQILKNKGLTPKRNKDNRNSRVK
KRKKYQKAQKKLKSVRAVYSGGQSGVYEGEKTGIKKGLTRSVKFK
Ligand information
>7d4i Chain SA (length=1337) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagauaguuaucugguugauccugccaguagucauaugcuugucucaaag
auuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcga
aaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacug
ugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagag
auguauuuauuagagucuucggacucuuugaugauucauaauaacuuuuc
gaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuau
caacuuucgaugguaggauaguggccuaccaugguuucaacgggagcagg
cgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacg
auacagggcccauucgggucuuguaauuggaaugaguacaauguaaauac
cuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaa
uuccagcuccaauagcguauauuaagcucguaguugaacugggcccgguu
ggccgguccgauuuucgugacuggccaacggggccuuuccuucugguuua
cuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauua
gcauggaauaauagaauaggguuugguucuaucuaggaccaugauuaaua
gggacggucgggggcaucaguauucaauugucagaggugaaauucuugga
uuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauu
aaucaagaacguagggaucgggugguguuuuuuuaaugacccacucggca
ccuuggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggc
accaccaggaguggagccugcggcucaacacggggaaacucaccaggucc
agacacaauaaggauugacauucuugauuuugugggugguggugcauuga
ugcccuuguucugggcccgcgcgcuacacugacggagccagcgagucuaa
ccuuggccgagaggucuuggaaacuccgucgugcuggggauagagcauug
uaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcu
ugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguacc
gauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaac
uccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacua
aauuccguaggugaaccugcggaaggaucauuaaaga
.................................<<<<<<...<.<.....
.....<<<.<<<..<<....<<.....................>>.>>..
.....<<<..<<..<<....<<<..................<.....<<.
<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>
>><...<<<<<<..<<<<..>>>>..............>>>>>>.....>
...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<..
..<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.>>>>>
>.........<<<....<<<.....>>>..>>>.......>.>.....<<
.<<<<..<<<<....>>>>..>>>>..>>......<<..<..........
.>..>>.........<<<<<<.......<<<....>>>............
......>>>>>>..>>>>>>.....<.<<...<<<.<<...<<<<<.<<<
<<<<<<<<<<<...>>>.>>>>>>>>>>>.>>>>>............<<<
<<.<<...........<<.......>>.<<<.....>>>...........
.>>.>>..>>>............<..<.......>..>......>>....
<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>.....
.>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...
>>>...>>.>..<<<..<<<<<<<<.<<..........>>>>>>>>>>..
>>>..................<<.........>>.....<<<<<<<<<<<
<..<<.<<<<<<..<<<.<<<<.......................<<...
...<<<<<.....................>>>>>......<<<.......
.>>>.....>>......>>>>.>>>.....<<<<<<<.............
<<..<<<<....>>>>..>>...>>>>>>>......<....<<<<<<...
.......>>>>>>....>.....>>>>>>....<<<<<<<.........>
>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<
....<<<<<<<<.<<<....<<..........<<<.<<<..<<<......
>>>..>>>.>>>..........>>....>>>.>>>>>>>>...>>.>>>>
..<<<<<<<<<....>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7d4i Cryo-EM structure of 90S small ribosomal precursors complex with Dhr1
Resolution4.0 Å
Binding residue
(original residue number in PDB)		Y442 Y542 K548 K553 R554 K556 N558 R559 N560 R562 V563 K565 R566 K568 K574 K575 S578 K595 K599
Binding residue
(residue number reindexed from 1)		Y12 Y28 K34 K39 R40 K42 N44 R45 N46 R48 V49 K51 R52 K54 K60 K61 S64 K81 K85
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7d4i, PDBe:7d4i, PDBj:7d4i
PDBsum7d4i
PubMed
UniProtQ12136|SAS10_YEAST Something about silencing protein 10 (Gene Name=SAS10)

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