Structure of PDB 7ase Chain 5 Binding Site BS02

Receptor Information

>7ase Chain 5 (length=421) Species: 5693 (Trypanosoma cruzi)

QATVNIGTIGHVAHGKSTVVKALSGVKTQKYHREAVMNITIHLGYANAKV
FKCDKCELPAAFHAFPSSQPDKTDCPTCGSPLTLKRHFSFVDCPGHDVLM
ATMLNGAAIMDAALLLIAANEPFPQPQTLEHLKAVEIMRLANLVILQNKI
DLVGEVHAQDQYHKIRNYIDSTIGSNIPIIPISAQLKRNIDYLLEYLCHI
PLPTRQLNCPAHMTVVRSFDINKPGEVDIENLRGGVAGGTVTRGIIRVNQ
VLEIRPGQVHAQTGGTFSCTPLRTRALTLKAEDNSLQYAVPGGLIAVGTT
LDPTLTRQDKMVGHMIADEGSLPEVYAEIEVQYFLFEEMVGRSKQRDRNA
KRVQKLNLQETLQINVGTLTAGATVVNITKNPDIAKLTLVTPVCCTLDEH
IAISRLVEKNFRLIGWGIIRR

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7ase Chain 5 Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ase Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
• Resolution: 3.33 Å
• Binding residue (original residue number in PDB): S66 T89
• Binding residue (residue number reindexed from 1): S17 T40
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.3: protein-synthesizing GTPase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003743 translation initiation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0001731 formation of translation preinitiation complex
• GO:0006412 translation
• GO:0006413 translational initiation

Cellular Component

• GO:0005829 cytosol
• GO:0005850 eukaryotic translation initiation factor 2 complex

External links

• PDB: RCSB:7ase, PDBe:7ase, PDBj:7ase
• PDBsum: 7ase
• PubMed: 33357443
• UniProt: Q4CPV7