Structure of PDB 8h6k Chain 4G Binding Site BS02

Receptor Information
>8h6k Chain 4G (length=801) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDEKDDEEADAIYAALDK
RMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSI
PEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGG
DINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGT
EMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDI
RAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVEL
WLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKI
IDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEE
EDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKN
HGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQ
ANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEW
VQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGL
KKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRL
EYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKK
CEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFEL
QHGTEEQQEEVRKRCESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGR
I
Ligand information
>8h6k Chain 4A (length=128) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuauugcuaauuuuuucccccgccgugacgacuugcaauauagucggca
cuggcaauuuuugacagucucgagacug
...................<<<<<.<<<.....<<.....>>..>>>>>>
>>....................<<<<<<.<<<<<........>>>>>.>>
>.>>>.........<<<<<<<>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8h6k Structural Insights into Human Exon-defined Spliceosome Prior to Activation.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N168 K169 R172 R175 E177 K178 Q825 T828
Binding residue
(residue number reindexed from 1)		N108 K109 R112 R115 E117 K118 Q689 T692
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0008380 RNA splicing
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h6k, PDBe:8h6k, PDBj:8h6k
PDBsum8h6k
PubMed38658629
UniProtO94906|PRP6_HUMAN Pre-mRNA-processing factor 6 (Gene Name=PRPF6)

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