Structure of PDB 8h6k Chain 4B Binding Site BS02

Receptor Information
>8h6k Chain 4B (length=256) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEIEWWDSYIIFGITNLVEHPAQLNPPVTLGVYLTKKEQKKLRRQTRREA
QKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAK
RQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAK
KFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDT
NKCVLVWEGTAKDRSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSES
VLESTD
Ligand information
>8h6k Chain 4A (length=128) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuauugcuaauuuuuucccccgccgugacgacuugcaauauagucggca
cuggcaauuuuugacagucucgagacug
...................<<<<<.<<<.....<<.....>>..>>>>>>
>>....................<<<<<<.<<<<<........>>>>>.>>
>.>>>.........<<<<<<<>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8h6k Structural Insights into Human Exon-defined Spliceosome Prior to Activation.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K442 K447 R449 R450 R465 H511 K526 Q566 L567
Binding residue
(residue number reindexed from 1)		K36 K41 R43 R44 R59 H105 K120 Q160 L161
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8h6k, PDBe:8h6k, PDBj:8h6k
PDBsum8h6k
PubMed38658629
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

[Back to BioLiP]