Structure of PDB 6qnr Chain 49 Binding Site BS02

Receptor Information

>6qnr Chain 49 (length=181) Species: 300852 (Thermus thermophilus HB8)

PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK

Ligand information

>6qnr Chain 14 (length=2876)

ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaug
aaggacguggcuaccugcgauaagccagggggagccgguagcgggcgugg
aucccuggauguccgaaugggggaacccggccggcgggaacgccggucac
cgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccaga
ggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggac
cagccuaaaccguccggcuuguccgggcggggucguggggcccucggaca
ccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggu
gaaagccccguaggcgaaagguggggggauaggugaggguacccgaguac
cccgugguucguggagccaugggggaaucugggcggaccaccgccuaagg
cuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggug
aaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuac
aagcagucacggccccgcaagggguuguggcgugccuauugaagcaugag
ccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcgua
gggaaaccgaguccgaacagggcgcaaacggcccgaaaaguccgcggccg
uggacccgaaaccgggcgagcuagcccuggccagggugaagcugggguga
gacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagc
uggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccc
cgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagca
cugauagggcuagggggcccaccagccuaccaaacccugucaaacuccga
agggucccagguggagccugggagugagggcgcgagcgauaacguccgcg
uccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucuggg
cuaagugguaaaggauguggcgccgcgaagacagccaggauguugaucau
uuaaagagugcucacuggucgaguggcgccgcgccgaaaaugaucggggc
uuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguag
gggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagg
uaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaauc
ccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggg
uuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgg
uuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcua
gggggaccggagccauggacgagcccggccagaagcgcagggugggaggu
aggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgg
gugacaaccccccgaagccagggagccaagaaaagccucuaagcacaacc
ugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcac
ucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccgu
aacuucgggagaaggggugcucccuggggugaugagccccggggagccgc
agugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaac
ucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaa
ggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaa
cuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccu
gcacgaaaagcguaacgaccggagcgcugucucggcgagggacccgguga
aauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagac
cccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcgu
aggauaggugggagccugugaacccccgccuccgggugggggggaggcgc
cggugaaauaccacccuggcgcggcugggggccuaacccucggauggggg
gacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaaggua
acggaggcgcccaaagguccccucaggcgggacggaaauccgccggagag
cgcaaggguagaagggggccugacugcgaggccugcaagccgagcagggg
cgaaagccgggccuagugaaccgguggucccguguggaagggccaucgau
caacggauaaaaguuaccccggggauaacaggcugaucucccccgagcgu
ccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccug
gggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcac
gcgagcuggguucagaacgucgugagacaguucggucucuauccgccacg
ggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagg
gacgcaccucugguuucccagcugucccuccaggggcauaagcuggguag
ccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgcc
ccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacc
acccgguggaugggccggggguguaagcgccgcgaggcguugagccgacc
ggucccaaucguccgaggucuugacc

<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<....
..<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<
<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>.
..........<<....>>...<<<<<.....<<.....>>....>>>>>.
..<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<
<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.
....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<
<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>
>......>>.>>>>>>.>>...............<<....>>....>>..
.......<<<<....>>>>..................>>>>>>>>>>>..
.....<<<<<<<<<<<....>>>>>>>>>>>...<............>.<
<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...
<<....>>..<<<<.....>>>>.....<<...>>....>>>>>>>>>>>
>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<....
..>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>
>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<
<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<..
.<<<<<<<<...<<<.<........>.>.>>...>>>>>>>>..>>.>..
.>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>
>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
<...........<<..<<<<<<<<<........<<<<..<<.......>>
...............>>>>....>>>>>>>>>.>>..........)))..
....>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>
>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>
>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>
>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>.
...((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<
........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..
<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<
.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>
>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>
>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>
>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<..
.............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>...
.........<<<<<<<<<..<<<.........>>>..<<<<<<<.....<
<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...
<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<<.....>>>>>>..
...>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>..
...>.....<<<<<........>>>>>..<<<<<<<<.<<<.........
<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.....
......<<<....<<.......<<<<<<<<....>>>>>>>>....>>..
............>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>
....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<.........
..>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<
<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<
<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..
...........>>>>..>>>>>>.......<<<<...<<<<<<...<<..
.....>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<
<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..
>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>
>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>
>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>
>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>
>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<......
.>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>
>>>.>>>...>>>>....>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qnr Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): K36 N40 G42 L43 G44 E45 T71 K74 N79 F80 I88 R91 S124 D126 R128 N132 L133 R136 G154 M155 D156 A158
• Binding residue (residue number reindexed from 1): K35 N39 G41 L42 G43 E44 T70 K73 N78 F79 I87 R90 S123 D125 R127 N131 L132 R135 G153 M154 D155 A157

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6qnr, PDBe:6qnr, PDBj:6qnr
• PDBsum: 6qnr
• PubMed: 31175275
• UniProt: Q5SHQ0|RL5_THET8 Large ribosomal subunit protein uL5 (Gene Name=rplE)