Structure of PDB 6qnr Chain 41 Binding Site BS02

Receptor Information

>6qnr Chain 41 (length=181) Species: 300852 (Thermus thermophilus HB8)

PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK

Ligand information

>6qnr Chain 1H (length=2890)

ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaug
aaggacguggcuaccugcgauaagccagggggagccgguagcgggcgugg
aucccuggauguccgaaugggggaacccggccggcgggaacgccggucac
cgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguaccc
agaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggg
gaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgg
accgaauccccagccuagccgaagcuguugggaagcagcgccagagaggg
ugaaagccccguaggcgaaagguggggggauaggugaggguacccgagua
ccccgugguucguggagccaugggggaaucugggcggaccaccgccuaag
gcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggu
gaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuua
caagcagucacggccccgcaagggguuguggcgugccuauugaagcauga
gccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcgu
agggaaaccgaguccgaacagggcgcaaacggccgaaaaguccgcggccg
uggacccgaaaccgggcgagcuagcccuggccagggugaagcugggguga
gacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagc
uggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccc
cgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagca
cugauagggcuagggggcccaccagccuaccaaacccugucaaacuccga
agggucccagguggagccugggagugagggcgcgagcgauaacguccgcg
uccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucuggg
cuaagugguaaaggauguggcgccgcgaagacagccaggauguuggagca
gccaucauuuaaagagugcguuagcucacuggucgaguggcgccgcgccg
aaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaug
accccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcg
agggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaa
agagggugagaaucccucucgccguaagcccaaggguuccuacgcaaugg
ucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagc
cgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggg
gacgcucuaggcuagggggaccggagccauggacgagcccggccagaagc
gcagggugggagguaggcaaauccgccucccaacaagcucugcguggugg
ggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagc
cucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggc
gggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucug
caaguuggccccguaacuucgggagaaggggugcucccuggggugaugag
ccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacac
agcucucugcgaacucguaagaggagguauagggagcgacgcuugcccgg
ugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggug
aacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgg
guaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggc
gagggacccggugaaauugaacuggccgugaagaugcggccuacccgugg
caggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuu
ggucgcgccugcguaggauaggugggagccugugaacccccgccuccggg
ugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaa
cccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacgga
aauccgccggagagcgcaaggguagaagggggccugacugcgaggccugc
aagccgagcaggggcgaaagccgggccuagugaaccgguggucccgugug
gaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcuga
ucucccccgagcguccacagcggcggggagguuuggcaccucgaugucgg
cucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcc
cauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggu
cucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacg
agaggaccggaagggacgcaccucugguuucccagcugucccuccagggg
cauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaa
gcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaag
gacccgggaagaccacccgguggaugggccggggguguaagcgccgcgag
gcguugagccgaccggucccaaucguccgaggucuugacc

.<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<....
..<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<
<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>
>>.>.........<<....>>...<<<<<.....<<.....>>....>>>
>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..
<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<
.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....
<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)
))......]].>>>>>>.]]...............<<....>>....]].
........<<<<....>>>>..................>>>>>>>>>>>.
......<<<<<<<<<<<....>>>>>>>>>>>...<............>.
<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>..
.<<....>>..<<<<.....>>>>.....<<..>>....>>>>>>>>>>>
>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<....
..>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>
>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<
<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<..
.<<<<<<<<.<..<<<<<......>>>>.>..>.>>>>>>>>..>>.>..
.>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>
>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
<...........<<..<<<<<<<<<........<<<<<.<<...<.....
..>...>>.........<<....>>...>>>>>....>>>>>>>>>.>>.
.........)))......>>>>>>.>>>...>>>>>>><<<<<<<<....
.>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<...
.>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....
<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.
....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>
>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<.
...<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<
<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>
<...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>
>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>
.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<........
.<.....<<<<<...............>>>>><<<<<<<<<<<<.....>
>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>.
.<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<
<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>.
.>>>>><<<<<<.......>>>>>>........<...........<<<<<
<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>
>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<
<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<
<<<<<<<<<...........<<.<<..<<<.......<<<<<<<....>>
>>>>>....>>>............>>.>>..>>>>>>>>>>>>>>>>...
<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>
>..)))>>>>>>.............>>>>..]]>>>>.......<<<<..
.<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.....)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......
........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>
>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>
>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<
<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>
>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qnr Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): K36 V38 N40 G42 G44 E45 K47 T71 A73 K74 K75 F80 L82 I88 R91 S124 D126 R128 N132 L133 G134 L135 R153 G154 M155 D156
• Binding residue (residue number reindexed from 1): K35 V37 N39 G41 G43 E44 K46 T70 A72 K73 K74 F79 L81 I87 R90 S123 D125 R127 N131 L132 G133 L134 R152 G153 M154 D155

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6qnr, PDBe:6qnr, PDBj:6qnr
• PDBsum: 6qnr
• PubMed: 31175275
• UniProt: Q5SHQ0|RL5_THET8 Large ribosomal subunit protein uL5 (Gene Name=rplE)