Structure of PDB 9fbv Chain 4 Binding Site BS02

Receptor Information

>9fbv Chain 4 (length=60) Species: 679895 (Escherichia coli BW25113)

MKKDIHPKYEEITASCSCGNVMKIRSTVGHDLNLDVCSKCHPFFTGKQGR
VDRFNKRFNI

Ligand information

>9fbv Chain A (length=1519)

aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaa
cacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacga
guggcggacgggugaguaaugucugggaaacugccugauggagggggaua
acuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagg
gggccucuugccaucggaugugcccagaugggauuagcuaguaggugggg
uaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccag
ccacacuggaacugagacacgguccagacuccuacgggaggcagcagugg
ggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaug
aagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaa
aguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaa
cuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaa
uuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaau
ccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucuc
guagagggggguagaauuccagguguagcggugaaaugcguagagaucug
gaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucag
gugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgc
cguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaa
cgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaa
ugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgau
gcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagag
augagaaugugccuucgggaaccgugagacaggugcugcauggcugucgu
cagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccu
uauccuuuguugccagcgguccggccgggaacucaaaggagacugccagu
gauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacg
accagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccuc
gcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucu
gcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaug
ccacggugaauacguucccgggccuuguacacaccgcccgucacaccaug
ggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuua
ccacuuugugauucaugacuggggugaagucguaacaagguaaccguagg
ggaaccugcgguuggauca

.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....
<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..
>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....
.<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<
<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<..
.......>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>
>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.
........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.
.....<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<
<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...
<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>....
......<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....
.<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<
<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>
>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...
>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>
..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..)
)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)
))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<..
......>>..........<<<<<<<......<<<<<<<..<<<<<<<...
.>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.....
..<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<
<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<
.....>>>>>........>>>>.........>>>...>>>>>>>>>...>
>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<
....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<.
.......>>>>>>>....>.....>>>>>>....<<<<<<<.........
>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<
<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>
>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<
....>>>>>>>>>......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 9fbv Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): R59 R63
• Binding residue (residue number reindexed from 1): R53 R57

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0006413 translational initiation
• GO:1904689 negative regulation of cytoplasmic translational initiation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:9fbv, PDBe:9fbv, PDBj:9fbv
• PDBsum: 9fbv
• PubMed: 38826346
• UniProt: P0A7M9|RL31_ECOLI Large ribosomal subunit protein bL31 (Gene Name=rpmE)