Structure of PDB 8iuh Chain 4 Binding Site BS02

Receptor Information
>8iuh Chain 4 (length=365) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKWKNWEKALLRKSVVS
DRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQGREAEKEIQDINQL
PEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQEWS
REEEERLQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKALKRKE
WTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWTKSLDPG
LKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLH
FSLKKGRWNLKEEEQLIELIEKYGVGHWAKIASELPHRSGSQCLSKWKIM
MGKKQGLRRRRRRAR
Ligand information
>8iuh Chain Y (length=81) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gctgccgaagcgagcacggtgctttccacaagatatataaagccaagaaa
tcgaaatactttcaagttacggtaagcatat
Receptor-Ligand Complex Structure
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PDB8iuh Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		Y372 R373 I388 Y389 F425 R440
Binding residue
(residue number reindexed from 1)		Y224 R225 I240 Y241 F277 R292
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
Biological Process
GO:0042795 snRNA transcription by RNA polymerase II
GO:0042796 snRNA transcription by RNA polymerase III
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0019185 snRNA-activating protein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iuh, PDBe:8iuh, PDBj:8iuh
PDBsum8iuh
PubMed37165065
UniProtQ5SXM2|SNPC4_HUMAN snRNA-activating protein complex subunit 4 (Gene Name=SNAPC4)

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