Structure of PDB 6zp4 Chain 4 Binding Site BS02

Receptor Information
>6zp4 Chain 4 (length=144) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYEELLNRVFNIMRRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKH
LLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCR
SPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6zp4 Chain 4 Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6zp4 Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		C302 C305
Binding residue
(residue number reindexed from 1)		C117 C120
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, RNA binding
GO:0031369 translation initiation factor binding
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001731 formation of translation preinitiation complex
GO:0002176 male germ cell proliferation
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0008584 male gonad development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zp4, PDBe:6zp4, PDBj:6zp4
PDBsum6zp4
PubMed32680882
UniProtP20042|IF2B_HUMAN Eukaryotic translation initiation factor 2 subunit 2 (Gene Name=EIF2S2)

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