Structure of PDB 6esb Chain 4 Binding Site BS02

Receptor Information

>6esb Chain 4 (length=318) Species: 1891762 (Betapolyomavirus hominis)

PKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFS
LKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQ
TEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLM
NYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNE
NTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADI
CGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRV
DGQPMYGMESQVEEVRVF

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6esb Chain 3 Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6esb The Structure of an Infectious Human Polyomavirus and Its Interactions with Cellular Receptors.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): S213 E216
• Binding residue (residue number reindexed from 1): S197 E200
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005198 structural molecule activity

Biological Process

• GO:0019062 virion attachment to host cell
• GO:0046718 symbiont entry into host cell
• GO:0075513 caveolin-mediated endocytosis of virus by host cell

Cellular Component

• GO:0019028 viral capsid
• GO:0039620 T=7 icosahedral viral capsid
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6esb, PDBe:6esb, PDBj:6esb
• PDBsum: 6esb
• PubMed: 29706532
• UniProt: P03088|VP1_POVBK Major capsid protein VP1