Structure of PDB 8ceo Chain 3 Binding Site BS02

Receptor Information
>8ceo Chain 3 (length=131) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKDMCPICKTDRYLSPDVKFLVNPECYHRICESCVDRIFSLGPAQCPYKG
CDKILRKNKFKTQIFDDVEVEKEVDIRKRVFNVFNKTIDDFNGDLVEYNK
YLEEVEDIIYKLDHGIDVAKTEEKLRTYEEL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ceo Chain 3 Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ceo Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C34 H36 C54 C59
Binding residue
(residue number reindexed from 1)		C26 H28 C46 C51
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex
GO:0070985 transcription factor TFIIK complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ceo, PDBe:8ceo, PDBj:8ceo
PDBsum8ceo
PubMed37014863
UniProtQ03290|TFB3_YEAST RNA polymerase II transcription factor B subunit 3 (Gene Name=TFB3)

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