Structure of PDB 5wis Chain 2m Binding Site BS02

Receptor Information
>5wis Chain 2m (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAE
VVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQR
TRTNARTRKGPRKTVAGKKKAP
Ligand information
>5wis Chain 2w (length=72) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccggauagcucagggagagcaggggauugaaaauccccguguccuuggu
ucgauuccgaguccgggcacca
<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.
......>>>>>>>>>>>.....
Receptor-Ligand Complex Structure
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PDB5wis Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Resolution2.703 Å
Binding residue
(original residue number in PDB)		K120 A123
Binding residue
(residue number reindexed from 1)		K118 A121
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wis, PDBe:5wis, PDBj:5wis
PDBsum5wis
PubMed28934499
UniProtP80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)

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