Structure of PDB 8vtw Chain 2Z Binding Site BS02
Receptor Information
>8vtw Chain 2Z (length=201) Species:
300852
(Thermus thermophilus HB8) [
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MEYRLKAYYREGEKPSALRRAGKLPGVMYNRHLNRKVYVDLVEFDKVFRQ
ASIHHVIVLELPDGQSLPTLVRQVNLDKRRRRPEHVDFFVLSDEPVEMYV
PLRFVGTPAGVRAGGVLQEIHRDILVKVSPRNIPEFIEVDVSGLEIGDSL
HASDLKLPPGVELAVSPEETIAAVVPPEDVEKLAEEAAAEVAEPEVIKKG
K
Ligand information
>8vtw Chain 2B (length=120) [
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ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacg
gaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccuggga
gaguaggucggugcggggga
<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>..
.....>>>.>>>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB
8vtw
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Resolution
2.35 Å
Binding residue
(original residue number in PDB)
R10 P15 R19 Y29 N30 R31 N34 K36 R72 Q73 R79 E84 H85 D87 F89
Binding residue
(residue number reindexed from 1)
R10 P15 R19 Y29 N30 R31 N34 K36 R72 Q73 R79 E84 H85 D87 F89
External links
PDB
RCSB:8vtw
,
PDBe:8vtw
,
PDBj:8vtw
PDBsum
8vtw
PubMed
39039256
UniProt
Q5SHZ1
|RL25_THET8 Large ribosomal subunit protein bL25 (Gene Name=rplY)
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