Structure of PDB 8vtx Chain 2S Binding Site BS02

Receptor Information
>8vtx Chain 2S (length=110) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLTAYERRKFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSAS
SLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALA
EGAREGGLEF
Ligand information
>8vtx Chain 2B (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacg
gaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccuggga
gaguaggucggugcggggga
.<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>..
.>...>>>.>>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		K11 R15 R25 F29 R30 S31 L32 K33 H34 Y36 Q38 G45 V46 T47 S50 K62 T63 Y92 K93 H95 R97
Binding residue
(residue number reindexed from 1)		K9 R13 R23 F27 R28 S29 L30 K31 H32 Y34 Q36 G43 V44 T45 S48 K60 T61 Y90 K91 H93 R95
External links
PDB RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
PDBsum8vtx
PubMed39039256
UniProtQ5SHQ4|RL18_THET8 Large ribosomal subunit protein uL18 (Gene Name=rplR)

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