Structure of PDB 8ife Chain 2P Binding Site BS02

Receptor Information
>8ife Chain 2P (length=131) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGD
MVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNK
GEMKGSAITGPVAKECADLWPRIASNAGSIA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8ife Chain 1A Residue 5284 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ife Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside.
Resolution2.57 Å
Binding residue
(original residue number in PDB)		I45 K46
Binding residue
(residue number reindexed from 1)		I36 K37
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001223 transcription coactivator binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0070180 large ribosomal subunit rRNA binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006610 ribosomal protein import into nucleus
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0032986 protein-DNA complex disassembly
GO:0050821 protein stabilization
GO:0070314 G1 to G0 transition
GO:0072717 cellular response to actinomycin D
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1903450 regulation of G1 to G0 transition
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0032991 protein-containing complex
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ife, PDBe:8ife, PDBj:8ife
PDBsum8ife
PubMed38227611
UniProtP62829|RL23_HUMAN Large ribosomal subunit protein uL14 (Gene Name=RPL23)

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