Structure of PDB 8vtx Chain 2G Binding Site BS02
Receptor Information
>8vtx Chain 2G (length=181) Species:
300852
(Thermus thermophilus HB8) [
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PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK
Ligand information
>8vtx Chain 2B (length=120) [
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ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacg
gaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccuggga
gaguaggucggugcggggga
.<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>..
.>...>>>.>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB
8vtx
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
P2 N27 V28 W29 Q66 K67 A69 V70 R91 V92 T93 R95 R96 R98
Binding residue
(residue number reindexed from 1)
P1 N26 V27 W28 Q65 K66 A68 V69 R90 V91 T92 R94 R95 R97
External links
PDB
RCSB:8vtx
,
PDBe:8vtx
,
PDBj:8vtx
PDBsum
8vtx
PubMed
39039256
UniProt
Q5SHQ0
|RL5_THET8 Large ribosomal subunit protein uL5 (Gene Name=rplE)
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