Structure of PDB 6ip6 Chain 2E Binding Site BS02
Receptor Information
>6ip6 Chain 2E (length=176) Species:
9606
(Homo sapiens) [
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QDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSK
ARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDT
GNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIG
AKHRISKEEAMRWFQQKYDGIILPGK
Ligand information
>6ip6 Chain 1B (length=120) [
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gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcuu
<<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..
>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>..
..>>>>>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB
6ip6
HCV IRES Captures an Actively Translating 80S Ribosome.
Resolution
4.5 Å
Binding residue
(original residue number in PDB)
P11 M12 Q46 T47 V49 C72 T73 R75 G138 I141 D143 K144 R147 C150 I151 K154 H155 R156
Binding residue
(residue number reindexed from 1)
P9 M10 Q44 T45 V47 C70 T71 R73 G136 I139 D141 K142 R145 C148 I149 K152 H153 R154
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003723
RNA binding
GO:0003735
structural constituent of ribosome
GO:0005515
protein binding
GO:0008097
5S rRNA binding
GO:0019843
rRNA binding
GO:0031625
ubiquitin protein ligase binding
GO:1990948
ubiquitin ligase inhibitor activity
Biological Process
GO:0000027
ribosomal large subunit assembly
GO:0002181
cytoplasmic translation
GO:0006364
rRNA processing
GO:0006412
translation
GO:0006605
protein targeting
GO:0010628
positive regulation of gene expression
GO:0032092
positive regulation of protein binding
GO:0032435
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504
protein localization to nucleus
GO:0042273
ribosomal large subunit biogenesis
GO:0050821
protein stabilization
GO:1901796
regulation of signal transduction by p53 class mediator
GO:1901798
positive regulation of signal transduction by p53 class mediator
GO:1904667
negative regulation of ubiquitin protein ligase activity
GO:2000059
negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435
negative regulation of protein neddylation
Cellular Component
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005730
nucleolus
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005840
ribosome
GO:0016020
membrane
GO:0022625
cytosolic large ribosomal subunit
GO:0022626
cytosolic ribosome
GO:0032991
protein-containing complex
GO:0070062
extracellular exosome
GO:1990904
ribonucleoprotein complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:6ip6
,
PDBe:6ip6
,
PDBj:6ip6
PDBsum
6ip6
PubMed
31080011
UniProt
P62913
|RL11_HUMAN Large ribosomal subunit protein uL5 (Gene Name=RPL11)
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