Structure of PDB 8jd5 Chain 2 Binding Site BS02

Receptor Information

>8jd5 Chain 2 (length=785) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRI
NRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASAITGVIGGSYSDV
SIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAE
ILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSR
AAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGW
GALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFRE
FWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHR
ALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFG
DGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPA
SRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPN
ASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPV
VKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCY
SALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAW
LVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAF
KTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVS
VSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPT

Ligand information

Ligand ID

GLU

InChI

InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChIKey

WHUUTDBJXJRKMK-VKHMYHEASA-N

SMILES

Software	SMILES
ACDLabs 12.01	O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0	C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0	C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370	N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370	N[CH](CCC(O)=O)C(O)=O

Formula

C5 H9 N O4

Name

GLUTAMIC ACID

PDB chain

8jd5 Chain 2 Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8jd5 Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	R57 R61 S143 S145 T168 K377
Binding residue (residue number reindexed from 1)	R35 R39 S96 S98 T121 K330
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0001641	group II metabotropic glutamate receptor activity
GO:0004930	G protein-coupled receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0097110	scaffold protein binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007215	glutamate receptor signaling pathway
GO:0007216	G protein-coupled glutamate receptor signaling pathway
GO:0007268	chemical synaptic transmission
GO:0010467	gene expression
GO:0014047	glutamate secretion
GO:0014048	regulation of glutamate secretion
GO:0014059	regulation of dopamine secretion
GO:0033554	cellular response to stress
GO:0035095	behavioral response to nicotine
GO:0042220	response to cocaine
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060292	long-term synaptic depression
GO:0090461	intracellular glutamate homeostasis
GO:0099171	presynaptic modulation of chemical synaptic transmission
GO:2001023	regulation of response to drug

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097449	astrocyte projection
GO:0098978	glutamatergic synapse

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8jd5, PDBe:8jd5, PDBj:8jd5
PDBsum	8jd5
PubMed	37286794
UniProt	Q14416\|GRM2_HUMAN Metabotropic glutamate receptor 2 (Gene Name=GRM2)

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