Structure of PDB 8jd3 Chain 2 Binding Site BS02

Receptor Information

>8jd3 Chain 2 (length=774) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRI
NRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLTAITGVIGGSYS
DVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAM
AEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAM
SRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASD
GWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWF
REFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNM
HRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDR
FGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPL
PASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYW
PNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNAT
PVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSV
CYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVV
AWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLY
AFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC
VSVSLSGSVVLGCLFAPKLHIILF

Ligand information

Ligand ID

GLU

InChI

InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChIKey

WHUUTDBJXJRKMK-VKHMYHEASA-N

SMILES

Software	SMILES
ACDLabs 12.01	O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0	C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0	C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370	N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370	N[CH](CCC(O)=O)C(O)=O

Formula

C5 H9 N O4

Name

GLUTAMIC ACID

PDB chain

8jd3 Chain 2 Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8jd3 Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	R57 R61 S143 Y144 S145 A166 T168 D295
Binding residue (residue number reindexed from 1)	R35 R39 S98 Y99 S100 A121 T123 D250
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0001641	group II metabotropic glutamate receptor activity
GO:0004930	G protein-coupled receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0097110	scaffold protein binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007215	glutamate receptor signaling pathway
GO:0007216	G protein-coupled glutamate receptor signaling pathway
GO:0007268	chemical synaptic transmission
GO:0010467	gene expression
GO:0014047	glutamate secretion
GO:0014048	regulation of glutamate secretion
GO:0014059	regulation of dopamine secretion
GO:0033554	cellular response to stress
GO:0035095	behavioral response to nicotine
GO:0042220	response to cocaine
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060292	long-term synaptic depression
GO:0090461	intracellular glutamate homeostasis
GO:0099171	presynaptic modulation of chemical synaptic transmission
GO:2001023	regulation of response to drug

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097449	astrocyte projection
GO:0098978	glutamatergic synapse

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8jd3, PDBe:8jd3, PDBj:8jd3
PDBsum	8jd3
PubMed	37286794
UniProt	Q14416\|GRM2_HUMAN Metabotropic glutamate receptor 2 (Gene Name=GRM2)

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