Structure of PDB 8i0r Chain 2 Binding Site BS02

Receptor Information
>8i0r Chain 2 (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVP
VPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTM
KSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFET
RLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLK
IPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTIDRTPWGELE
Ligand information
>8i0r Chain H (length=167) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuauc
aguuuaauaucugauguccucucgaggacggauuuuuggagcagggagau
ggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcagu
accuccaggaacggugc
................................................<<
<<........>>>>..<<<<<..>>>>>................<<<..<
<<....<<<<....>>>>..>>>.>>>..<<<<<<.<<<<<.........
....>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB8i0r Molecular Basis for the activation of Human spliceosome
Resolution3.0 Å
Binding residue
(original residue number in PDB)		S450 K453 R459 T481 W504
Binding residue
(residue number reindexed from 1)		S1 K4 R10 T32 W55
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0r, PDBe:8i0r, PDBj:8i0r
PDBsum8i0r
PubMed39068178
UniProtQ13435|SF3B2_HUMAN Splicing factor 3B subunit 2 (Gene Name=SF3B2)

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