Structure of PDB 8aw3 Chain 2 Binding Site BS02

Receptor Information
>8aw3 Chain 2 (length=177) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESVVYCDVFMQAALKEATCALEEGEVPVGCVLVKADSSTAAQAQAGDDLA
LQKLIVARGRNATNRKGHGLAHAEFVAVEELLRQADLADYVLYVVVEPCI
MCAAMLLYNRVRKVYFGCTNPRFGGNGTVLSVHNSYKGLIGYESCGGYRA
EEAVVLLQQFYRRENTNAPLGKRKRKD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8aw3 Chain 2 Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8aw3 Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3
Resolution3.6 Å
Binding residue
(original residue number in PDB)		H90 C136 C139
Binding residue
(residue number reindexed from 1)		H72 C99 C102
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing

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Molecular Function
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Biological Process
External links
PDB RCSB:8aw3, PDBe:8aw3, PDBj:8aw3
PDBsum8aw3
PubMed36347890
UniProtQ57W17

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