Structure of PDB 5z57 Chain 2 Binding Site BS02

Receptor Information
>5z57 Chain 2 (length=183) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKY
LQGKRGIEKPPFELPDFIKRTGIQEMREQKTMKSKMREKVRPKMGKIDID
YQKLHDAFFKWQLTIHGDLYYEGKEFETRKKPGDLSDELRISLGMPVPPP
WLIAMQRYGPPPSYPNLKIPGLNSPLYGDVFGT
Ligand information
>5z57 Chain H (length=136) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccggcuaagaucaaguguaguaucuguucuuaucaguu
uaauaucugauguccucucgaggacggauuuuuggagcagggagccacgc
aucgaccugguauugcaguaccuccaggaacggugc
...........................................<<<<<..
......>>>>>.<<<<<..>>>>>................<......><<
<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB5z57 Structure of the human activated spliceosome in three conformational states.
Resolution6.5 Å
Binding residue
(original residue number in PDB)		H478 T481 C505
Binding residue
(residue number reindexed from 1)		H18 T21 C45
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5z57, PDBe:5z57, PDBj:5z57
PDBsum5z57
PubMed29360106
UniProtQ13435|SF3B2_HUMAN Splicing factor 3B subunit 2 (Gene Name=SF3B2)

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