Structure of PDB 1ny2 Chain 2 Binding Site BS02

Receptor Information
>1ny2 Chain 2 (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1ny2 Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H57 W60D D189 A190 C191 E192 S195 S214 W215 G216
Binding residue
(residue number reindexed from 1)		H43 W50 D199 A200 C201 E202 S205 S226 W227 G228
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ny2, PDBe:1ny2, PDBj:1ny2
PDBsum1ny2
PubMed12598231
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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