Structure of PDB 8fc1 Chain 1y Binding Site BS02

Receptor Information

>8fc1 Chain 1y (length=97) Species: 83333 (Escherichia coli K-12)

TMNITSKQMEITPAIRQHVADRLAKLEKWQTHLINPHIILSKEPQGFVAD
ATINTPNGVLVASGKHEDMYTAINELINKLERQLNKLQHKGEARRAA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8fc1 Chain 1y Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fc1 Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): E11 I12
• Binding residue (residue number reindexed from 1): E10 I11
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0043024 ribosomal small subunit binding

Biological Process

• GO:0006417 regulation of translation
• GO:0009409 response to cold
• GO:0022611 dormancy process
• GO:0044238 primary metabolic process
• GO:0045900 negative regulation of translational elongation
• GO:0045947 negative regulation of translational initiation

Cellular Component

• GO:0005829 cytosol
• GO:0022627 cytosolic small ribosomal subunit

External links

• PDB: RCSB:8fc1, PDBe:8fc1, PDBj:8fc1
• PDBsum: 8fc1
• PubMed: 37452045
• UniProt: P0AD49|YFIA_ECOLI Ribosome-associated inhibitor A (Gene Name=raiA)