Structure of PDB 8vtu Chain 1S Binding Site BS02

Receptor Information
>8vtu Chain 1S (length=110) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLTAYERRKFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSAS
SLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALA
EGAREGGLEF
Ligand information
>8vtu Chain 1B (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacg
gaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccuggga
gaguaggucggugcggggga
<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>..
.....>>>.>>>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R15 K19 R25 F29 R30 S31 L32 K33 Y36 Q38 G45 V46 T47 S50 L54 K62 T63 K93 H95 G96 R97
Binding residue
(residue number reindexed from 1)		R13 K17 R23 F27 R28 S29 L30 K31 Y34 Q36 G43 V44 T45 S48 L52 K60 T61 K91 H93 G94 R95
External links
PDB RCSB:8vtu, PDBe:8vtu, PDBj:8vtu
PDBsum8vtu
PubMed39039256
UniProtQ5SHQ4|RL18_THET8 Large ribosomal subunit protein uL18 (Gene Name=rplR)

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