Structure of PDB 6xhy Chain 1S Binding Site BS02

Receptor Information

>6xhy Chain 1S (length=110) Species: 300852 (Thermus thermophilus HB8)

RLTAYERRKFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSAS
SLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALA
EGAREGGLEF

Ligand information

>6xhy Chain 1B (length=120)

ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacg
gaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccuggga
gaguaggucggugcggggga

<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>..
.....>>>.>>>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xhy Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): K11 R15 K19 R25 F29 R30 S31 L32 Y36 Q38 G45 V46 T47 S50 L54 N61 K62 T63 Y92 K93 H95 G96 R97
• Binding residue (residue number reindexed from 1): K9 R13 K17 R23 F27 R28 S29 L30 Y34 Q36 G43 V44 T45 S48 L52 N59 K60 T61 Y90 K91 H93 G94 R95

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6xhy, PDBe:6xhy, PDBj:6xhy
• PDBsum: 6xhy
• PubMed: 33462493
• UniProt: Q5SHQ4|RL18_THET8 Large ribosomal subunit protein uL18 (Gene Name=rplR)