Structure of PDB 5kcs Chain 1S Binding Site BS02

Receptor Information

>5kcs Chain 1S (length=116) Species: 83333 (Escherichia coli K-12)

DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAA
STVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHG
RVQALADAAREAGLQF

Ligand information

>5kcs Chain 1B (length=120)

ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacuca
gaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgag
aguagggaacugccaggcau

<<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>
>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>...
....>>...>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5kcs Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): D2 K3 K4 R15 R30 T31 R33 Y36 Q38 I40 V47 V54 E55 Y64 N67 K68 F97 Q98 H100 G101 R102
• Binding residue (residue number reindexed from 1): D1 K2 K3 R14 R29 T30 R32 Y35 Q37 I39 V46 V53 E54 Y63 N66 K67 F96 Q97 H99 G100 R101

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5kcs, PDBe:5kcs, PDBj:5kcs
• PDBsum: 5kcs
• PubMed: 27330110
• UniProt: P0C018|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)