Structure of PDB 8fnk Chain 10 Binding Site BS02

Receptor Information
>8fnk Chain 10 (length=416) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLPVSYSPGSVTSTAITAHCDVLSECVAKADELAVQLKTQEGMEEFVEEL
KTSATNEMTALVKQMQTTPLLQRAGMHELRRTLYYTTSLKERDWLEEKQY
TAAMRMLTVEVLRRDGDGVLSADDVLYVTTHVVTANFYNRHLWNRMEKSL
LKFSNYENIDMSSVKAFSTRLFKTRRGCAKETLDIRRKVLLAMSRRVGVL
ANDFDLPSLLGVLQCYTVHDLTPFHLEPLAIRATNHVGDFTPHECATLAH
VLRKWRTMRLEVCERLVERICTSDQLTHHMANAAMIAIRTCFNQVSDGGR
NAMNAEPTRQKLRAMGEQIGCRLDEVEYPALPVILSILDVVVTLKIYVPK
KCLQVIFSQANDMVAIVMEQKDDPITAEEGRQLQALLSHYGNDLAPELSQ
RMKEAFREGVLPDEAS
Ligand information
>8fnk Chain g (length=43) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaaaaaaaaaaaaaaaaaaaaaaaaaauuuuuuuuuuuuuuuu
...........................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8fnk Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R195 R196 Y199 Y200 Y242 K280 S283 T284 F287 R290 Q329 E359 H365 R368 K369 H394 R404 R415
Binding residue
(residue number reindexed from 1)		R80 R81 Y84 Y85 Y127 K165 S168 T169 F172 R175 Q214 E244 H250 R253 K254 H279 R289 R300
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0000963 mitochondrial RNA processing
GO:0016554 cytidine to uridine editing
GO:0048255 mRNA stabilization
Cellular Component
GO:0005739 mitochondrion
GO:0031019 mitochondrial mRNA editing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fnk, PDBe:8fnk, PDBj:8fnk
PDBsum8fnk
PubMed37410820
UniProtQ57VS6

[Back to BioLiP]