Structure of PDB 8y7e Chain 1 Binding Site BS02

Receptor Information
>8y7e Chain 1 (length=971) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNAR
TYMDVMREQHLTKEEREIRQQLAEKAERNRPLSDEELDAMFPEGYKVLPP
PAGYVPIMTGFHMQTEDRTMKSVNDQPSGNLPFLKPDDIQYFDKLLVDVD
ESTLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFN
QILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLI
DEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFA
VVASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHL
RSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWK
GIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEE
MKKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQL
VDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAAD
IDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQIC
GTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLG
EEYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQE
NCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGY
IAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALM
NEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLV
HRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGA
LEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAH
YPRIYNDDKNTYIRYELDYIL
Ligand information
>8y7e Chain H (length=50) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
augaguaaggaaaauaacgauucggggugacgcccgaagaauuuuugagc
....................<<<<<<......>>>>>>............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8y7e Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome
Resolution4.66 Å
Binding residue
(original residue number in PDB)		R517 R558 H1069 S1223 P1224 P1257 A1258 R1259
Binding residue
(residue number reindexed from 1)		R184 R225 H736 S890 P891 P924 A925 R926
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8y7e, PDBe:8y7e, PDBj:8y7e
PDBsum8y7e
PubMed38484052
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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