Structure of PDB 8i0p Chain 1 Binding Site BS02

Receptor Information
>8i0p Chain 1 (length=993) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVALLNDIPQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGG
KTPDPKMNARTYMDVMREQHLTKEEREIRQQLAEKARNRPLSDEELDAMF
PEGYKVLPPPAGYVPIRTPARKLTATPTPLTGFHMQTEDRTMKSVNDQPS
GNLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPM
RKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILY
KLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMIS
TMRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQAR
HTGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAA
LAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEY
ANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEIL
PPFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEA
EQYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVML
NGFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVV
MKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTP
PIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFE
LLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVC
TTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEM
GKDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHL
LNYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKV
RDVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
Ligand information
>8i0p Chain H (length=165) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucag
uuuaauaucugauguccucucgaggacggauuuuuggagcagggagaugg
aauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguac
cuccaggaacggugc
..............................................<<<<
........>>>>..<<<<<..>>>>>................<<<..<<<
<...<<<<....>>>>.>>>>.>>>..<<<<<<.<<<<<...........
..>>>>>..>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i0p Molecular Basis for the activation of Human spliceosome
Resolution3.4 Å
Binding residue
(original residue number in PDB)		P509 K513 R517 H1069 S1223 P1257
Binding residue
(residue number reindexed from 1)		P198 K202 R206 H758 S912 P946
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0p, PDBe:8i0p, PDBj:8i0p
PDBsum8i0p
PubMed39068178
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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