Structure of PDB 7ycx Chain 1 Binding Site BS02

Receptor Information
>7ycx Chain 1 (length=1451) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEHGGCG
RYQPRIRRSGLELYAEWKKKILLSPERVHEIFKRISDEECFVLGMEPRYA
RPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRN
EQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRL
KGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEI
VTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTG
YKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYN
ADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLT
AVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFS
LIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKK
SLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSI
ADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNR
ILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNV
EGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGG
REGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGE
DGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVL
SNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKI
FHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNI
HLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQ
SLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFL
LGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWV
NVISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEK
LVLRIRIMNDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLG
IEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVN
RQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGC
FDLLLDAEKCKYGMEIPAAAATSPSYSPTSPSYSPTSPSYSPTAAAAAAA
A
Ligand information
>7ycx Chain c (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauaaccggagagggaacccacu
.......................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ycx Structural basis of INTAC-regulated transcription.
Resolution4.18 Å
Binding residue
(original residue number in PDB)		R334 F431 D499
Binding residue
(residue number reindexed from 1)		R291 F388 D456
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
2.7.7.6: DNA-directed RNA polymerase.
3.1.13.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0019900 kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0050436 microfibril binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006353 DNA-templated transcription termination
GO:0006355 regulation of DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0033120 positive regulation of RNA splicing
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ycx, PDBe:7ycx, PDBj:7ycx
PDBsum7ycx
PubMed36869814
UniProtP24928|RPB1_HUMAN DNA-directed RNA polymerase II subunit RPB1 (Gene Name=POLR2A)

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