Structure of PDB 7tql Chain 1 Binding Site BS02

Receptor Information
>7tql Chain 1 (length=619) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EERAYDKAKRRIEKRRLEHSKNVTEKDKLRAPIICVLGHVDTGKTKILDK
LRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLI
IDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCP
FIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQ
QGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRL
AHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ
IRGLLTPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVA
YKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKT
SEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMAD
SLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQY
IFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDV
AKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD
EMQKSDWQLIVELKKVFEI
Ligand information
>7tql Chain 3 (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgau
ggaucgaaaccauccucugcuacca
<<<<<<<....<.........>...<<<<<.......>>>>>.....<<<
<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tql eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		N1103 S1104 P1107 V1109 E1142 N1144 H1145 C1158 K1160 S1168 M1171 R1174 H1175
Binding residue
(residue number reindexed from 1)		N503 S504 P507 V509 E542 N544 H545 C558 K560 S568 M571 R574 H575
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7tql, PDBe:7tql, PDBj:7tql
PDBsum7tql
PubMed35732735
UniProtO60841|IF2P_HUMAN Eukaryotic translation initiation factor 5B (Gene Name=EIF5B)

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