Structure of PDB 8cvm Chain 0 Binding Site BS02

Receptor Information
>8cvm Chain 0 (length=50) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVRPKITLACTECKERNYITKKNRRNNPDRMEMAKFCPRCRKHTAHRETR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8cvm Chain 0 Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8cvm Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		C16 C19 C43
Binding residue
(residue number reindexed from 1)		C10 C13 C37
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8cvm, PDBe:8cvm, PDBj:8cvm
PDBsum8cvm
PubMed36864821
UniProtQ6A6J5|RL331_CUTAK Large ribosomal subunit protein bL33A (Gene Name=rpmG1)

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