Structure of PDB 7po4 Chain za Binding Site BS01

Receptor Information

>7po4 Chain za (length=123) Species: 9606 (Homo sapiens)

TGPKFDIDMMVSLLRQENARDICVIQVPPEMRYTDYFVIVSGTSTRHLHA
MAFYVVKMYKHLKCKRDPHVKIEGKDTDDWLCVDFGSMVIHLMLPETREI
YELEKLWTLRSYDDQLAQIAPET

Ligand information

>7po4 Chain A (length=1145)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcaagauuuauagguagaggcgacaaaccu
accgagccuggugauagcugguuguccaagauagaaucuuaguucaacuu
uaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuag
uccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagaga
guaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaaga
aagcguucaagcucaacacaucccaaacauauaacugaacuccucacacc
caauuggaccaaucuaucacccuauagaagaacuaauguuaguauaagua
acaugaaaacauucuccuccgcauaagccugcgucagauuaaaaugaacu
gacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuaccc
ucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagu
aaaaggaacucggcaccuguuuaccaaaaacaucaccucuagcaucacca
guauuagaggcaguucagcugucucuuacuuuuaaccagugaaauugacc
ugcccgugaagaggcgggcauaacacagcaagacgagacccuauggagcu
uuaauuuauuaaugcaaacaguaccaaaccugcauuaaaagcaguacaug
cuaagacuucaccagucaaagcgaacuauccaauaacuugaccaacggaa
caaguuacccuaggcuaucuacuuucaaauuccucccuguacgaaaggac
aagagaaauaaggccuacuucacaaagcgccuuccccuaaaugauaucau
cucaacuuaguauuauacccacacccacccaagaacaggguuugu

<<<.......<<<<....................................
.<......>...............<<.....>>.............>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<.......>>....>>>.>>>>>...<<.......>>.
.....>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<
<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<
<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<
<...<...................<<<.........>>>...........
.<<<......>>>......................>...>>>>>>.....
...>>>>>>...<<<<<......>>>>>.........>>>>>><......
<<..<<<....>>><<<<..<<<<........<<<<<.<<.....>>.>>
>>>......<<<...<<<<.......................>>>>....
...>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<
<<.<<.......<<...<<<<<.....>>>>>...<<<<<<.........
....>>>>>>.......>>...>>.>>>>>>>>>>>>.>>.....>....
.<<<<<........>>>>>.......<<..<<<.......<<<.<.<<<<
........<<<<<<<<....<..>......>>>>>>>>...........<
<<..<<<<.....>>>>..>>>........<<<....>>>..........
..>>>>...>>>>....>>>.>>...<.<<<.<<<...............
..>>>.>>><<<<<...<<<....>>>.>>>>>.....<<.<........
....>.>>.......>..........<<<<.......>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7po4 Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
• Resolution: 2.56 Å
• Binding residue (original residue number in PDB): K147 H156
• Binding residue (residue number reindexed from 1): K60 H69

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0043023 ribosomal large subunit binding
• GO:0140978 mitochondrial large ribosomal subunit binding

Biological Process

• GO:0017148 negative regulation of translation
• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis
• GO:0070130 negative regulation of mitochondrial translation
• GO:0090071 negative regulation of ribosome biogenesis

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0005829 cytosol

External links

• PDB: RCSB:7po4, PDBe:7po4, PDBj:7po4
• PDBsum: 7po4
• PubMed: 35676484
• UniProt: Q96EH3|MASU1_HUMAN Mitochondrial assembly of ribosomal large subunit protein 1 (Gene Name=MALSU1)